Rigor in Science with good news for you, old-folks babblers.

NATURE, 27 July 2011. Neuronal basis of age-related working memory decline. Min Wang, Nao J. Gamo, Yang Yang, Lu E. Jin, Xiao-Jing Wang, Mark Laubach, James A. Mazer, Daeyeol Lee & Amy F. T. Arnsten  et al. Nature doi:10.1038/nature10243.

From the abstract: “Many of the cognitive deficits of normal ageing (forgetfulness, distractibility, inflexibility and impaired executive functions) involve prefrontal cortex (PFC) dysfunction1, 2, 3, 4. The PFC guides behaviour and thought using working memory5, which are essential functions in the information age. Many PFC neurons hold information in working memory through excitatory networks that can maintain persistent neuronal firing in the absence of external stimulation6. ” The punch line: ” These findings reveal the cellular basis of age-related cognitive decline in dorsolateral PFC, and demonstrate that physiological integrity can be rescued by addressing the molecular needs of PFC circuits.”

In short; guanfacine, a hypertension, ADD drug may “upgrade” older forgetful neurons to younger, “good memory” ones. How about that, hypertension drug restores memory (well in changos anyways)..only in america. Good job Amy.


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